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Sci Total Environ 532:821830 Csiszr J, Horvth E, Bela K, Gall (2016) Glutathione-Related enzyme system: glutathione reductase (GR), glutathione transferases (GSTs) and Glutathione peroxidases (GPXs)

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Thus, additional experiments could be conducted to systematically explore the effects of sulfonylureas on other ion channels besides K ATP channels, especially for some channels such as Kv2.1, which are closely linked to insulin release in -cells ( 2+ -dependent inhibition of K ATP by sulfonylureas, such as tolbutamide and glibenclamide, is evident, suggestive of the importance of Mg 2+ in the impact of sulfonylureas on ion channels, and it may be factored into devising related experiments

The preclinical side effect profile is favorable over 4 weeks: no pathological cardiac hypertrophy (some ERRalpha myocardial effects are physiological, dose is calibrated to remain in the adaptive range), no hepatic toxicity, no mitogenic signal at tested doses

Karmakar S, Rauth S, Nallasamy P, Perumal N, Nimmakayala RK, Leon F, et al

[DOI] [PubMed] [Google Scholar] 64.Circu M.L., Aw T.Y