SURMOUNT-1: Tirzepatide for Obesity The SURMOUNT-1 trial (NEJM, 2022) studied tirzepatide weight loss in 2,539 adults with obesity (without diabetes) over 72 weeks: STEP 1: Semaglutide for Obesity The STEP 1 trial (NEJM, 2021) studied semaglutide 2.4mg in 1,961 adults with obesity (without diabetes) over 68 weeks: Cross-Trial Summary Comparing across trials (with the caveat that indirect comparison has limitations): tirzepatide 15mg produced about 6 percentage points more weight loss than semaglutide 2.4mg over similar timeframes
Improvements in anxiety, depression, and a reductions in suicidal ideation and suicide attempts appear substantial
Freezing can ruin the structure of semaglutide, and the pen will no longer work
Usage Instructions of Ozempic Semaglutide 0.5 Injection Pen Ozempic is administered once a week, at any time of the day, with or without meals
The truth is, there isnt a better option just the one thats best for your body, lifestyle, and goals
Although many side effects are manageable, there are more serious risks associated with Ozempic, Wegovy, and the other weight loss injectables and pill forms that we noted above
