*Correspondence: Nady Braidy [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
Excessive weight gain associated with sulfonylureas and insulin treatment is not benign and results in worsening of well-known cardiovascular risk factors, potentially contributing to the increased macro-vascular risk
Similar mechanisms may be responsible for the enhanced vasodilatory action of peroxynitrite (ONOO) in the presence of GSH: peroxynitrite reacts with GSH to form S-nitrosothiols (RSNOs), which subsequently release NO over a prolonged period of time, thus extending NO's half-life and, as a result, relaxing vascular tone (25)
More broadly, compounds targeting core circadian regulators such as REV-ERBs, RORs, CRYs, and CK1 have already shown potential to fine-tune clock-controlled physiology in preclinical models (Solt et al., 2012
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