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The different subunits of the GABA A receptor are responsible for the binding of different drugs

Phenylephrine (PE) (Sigma-Aldrich) was added at 10 7 M for contraction

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Andreassen and colleagues (J Med Chem, 2021) reported a design campaign that combined sequence substitutions to suppress fibrillation with a fatty-acid acylation that promotes albumin binding, yielding a molecule with a much longer reported plasma half-life in their preclinical models

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