At the same time, withholding GLP-1RAs in the perioperative period is not without risk, as it may lead to suboptimal glycaemic control and loss of the cardiometabolic benefits associated with continued therapy [28, 42]
The typical dose escalation for semaglutide dosing follows this pattern: Each dose increase can trigger a fresh wave of bloating that typically peaks 3 to 5 days after the increase and then gradually subsides over the following 1 to 2 weeks
This overlap suggests that GLP-1 RAs and similar medications might also alter the reward-response pathways associated with substance use
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