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Updated May 2025

A version of this story originally appeared in the Good News newsletter

APD Causes and Risk Factors The Role of Histamine and Mast Cells in Autoimmune Progesterone Dermatitis Autoimmune Progesterone Dermatitis Treatments Autoimmune Progesterone Dermatitis and IVF Progesterone Hypersensitivity and Pregnancy Key Takeaways on Autoimmune Progesterone Dermatitis Frequently Asked Questions About Progestogen Hypersensitivity Autoimmune Progesterone Dermatitis: Quick Overview Rare immune reaction to progesterone or synthetic progestins Symptoms flare during the luteal phase when progesterone peaks Common symptoms include hives, itching, angioedema, and asthma-like reactions Diagnosis is clinical and based on hormone timing and response to progesterone withdrawal Treatment may include antihistamines, diet changes, hormone suppression, or desensitization Pregnancy and IVF are possible with specialized care Autoimmune Progesterone Dermatitis Symptoms Rashes associated with APD vary significantly in appearance depending on exactly how sensitive someone is to progesterone