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While acute inflammation has a protective role in eliminating harmful stimuli and initiating tissue repair, chronic inflammation creates a pro-tumorigenic microenvironment characterized by the sustained production of inflammatory mediators, including reactive oxygen species (ROS), chemokines, and cytokines

Hecquet S, Totoson P, Martin H, et al

Any medication adjustments, including changes to the tirzepatide dose or titration schedule, should be made under healthcare provider guidance based on overall tolerability and treatment goals

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doi: 10.1111/j.1460-9568.2011.07738.x 291 SamsE

A better understanding of the background biology will provide rationales for utilizing new compounds such as progesterone receptor modulators in the relevant conditions