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Pickart estimated lethal dose at approximately 22,500 mg for humans (300-fold above effective doses), with animal LD50 studies in mice showing 8 mg per 25g mouse (320 mg/kg, translating to ~22,400 mg for 154 lb human)

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Retinol and acids : Ingredients like glycolic acid, salicylic acid, and retinoids may reduce the efficacy of copper peptides while increasing skin sensitivity

And decades of preclinical research have been conducted specifically with the acetate form, providing a larger evidence base for injectable applications

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Panuszko, A., Szymczak, M., Duewska, J., Godlewska, J., Kuffel, A., & Brudziak, P