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Gradients in oxygen availability, nutrient supply, metabolic byproducts, immune surveillance, and drug penetration generate localized selective pressures that favor specific phenotypes ( This spatial organization is not stochastic but reflects ecological principles

DNA methylation landscapes in the pathogenesis of type 2 diabetes mellitus

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The nonBWS livers exhibited normal methylation at both IC1 and IC2, while the BWS samples were either IC2 LOM ( n = 2) or pUPD11 ( n = 2), consistent with clinical testing results in blood (Supplementary Table 1)