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Wegovy is broken down through proteolytic cleavage (similar to how your body breaks down proteins), while sertraline is metabolised by liver enzymes (cytochrome P450)
Guideline Recommendations The 2023 American Association of Clinical Endocrinology (AACE) Comprehensive Clinical Practice Guidelines for Medical Care of Patients with Obesity recommend GLP-1 receptor agonists, including semaglutide 2.4 mg, as first-line pharmacotherapy for adults with BMI 30 or BMI 27 with a weight-related complication
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However, not everyone experiences weight loss while on this medication due to individual differences in metabolism, body composition, and response to the drug
Key Takeaways Semaglutide can make you tired and cause fatigue, especially when your body is first adjusting to this class of weight loss medications
Because of the animal data linking GLP-1 receptor agonists to C-cell tumours, patients with a personal or family history of MTC should discuss the potential risks and benefits of Wegovy with their specialist
