doi: 10.1242/jcs.251819 247 DavdaDEl AzzounyMATomCTMBHernandezJLMajmudarJDKennedyRTet al
Astrogliosis is prevalent in the epilepsies, and interestingly a mouse forebrain neuron-specific knockout of SOD2 resulted in seizures, oxidative stress, and marked GFAP and vimentin gene upregulation, indicative of astrogliosis resulting from increased neuronal mtROS (Fulton et al., 2021)
Carbapenems thus provide a double benefit, lowering levels of both the parent drug and active metabolites
Botox relaxes facial muscles to soften wrinkles and fine lines, while dermal fillers restore lost volume and contour the face for a more youthful appearance
Funding The authors are grateful to the National Key Research and Development Program of China (2022YFD1300701, 2019YFE0115000) and the China Agriculture Research System of MOF and MARA (CARS-41)
This condition is responsible for more than 80% of skin cancer mortality