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1.3 ROS and autophagy interplay Autophagy is a catabolic process that is responsible for the degradation of intracellular proteins and damaged organelles in response to endogenous and exogenous stresses, including oxidative stress, endoplasmic reticulum stress, hypoxic stress, and nutrient and growth factor starvation (Galati et al., 2019)

If patients tell us about their alcohol use prior to surgery, we can treat them with medications that can reduce their risk of going into withdrawal, and well be on heightened alert if their anesthesia needs to be adjusted. Knowing this information in advance can also allow the medical team to offer the patient instructions on how to wean off alcohol ahead of surgery

Blood Res 57 , 4954 (2022)

This trade-off is consistent with in human evidence that sustained energetic stress can lead to progressive myelin loss even in the absence of overt axonal pathology (Ramos-Cabrer et al., 2025), suggesting that metabolic compensation may preserve short-term function at the expense of long-term myelin integrity

The resulting mixture was transferred to the pre-activated ultrafiltration membrane spin column, followed by washing with PBS (3 times), 1 TEAB (2 times), and finally reconstituted with TEAB

Medical monitoring ensures copper levels stay in safe range