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Available from: Ahmadi H, Fotesko K, Ba-Ali S, Hamann S, Kolko M

The SELECT trial is the only large-scale cardiovascular outcomes trial completed for either drug in an obesity population

Another breakthrough in obesity medication acceptance was the SELECT trial [7], the first cardiovascular outcome trial in persons with overweight and obesity with established cardiovascular disease (prior myocardial infarction, stroke or symptomatic peripheral artery disease) to show reduction in major adverse cardiovascular events (MACE) [7]

Stay physically active Regular physical activity is a cornerstone of weight maintenance

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Fluoxetine and fluvoxamine are potent and hit a broad array of P450 enzymes, while paroxetines effects are fairly specific for CYP2D6