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PEGylated lipid nanoparticles have demonstrated a tenfold enhancement in platinum circulation within the bloodstream

However, a multicenter study in 5,485 subjects with cardiovascular disease or diabetes mellitus showed that daily supplementation with folic acid (2.5 mg), vitamin B 12 (1 mg), and vitamin B6 (50 mg) lowered homocysteine concentrations but had no effect on fracture risk compared to placebo (118)

doi: 10.1002/mds.26102 202

The supernatant was used as the protein-bound fraction