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NOD itself is a recognized cardiovascular and metabolic risk factor and, in certain subgroups, may represent an early warning sign of serious underlying disease, including PDAC ( At the same time, PDAC remains intrinsically difficult to study due to its biological complexity, low incidence, and clinically silent progression until advanced stages, which limits early detection efforts

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2 There is insufficient data to recommend other formulations of vitamin B 12 replacement (e.g., nasal, sublingual, subcutaneous)