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In cases of significant transaminase elevation (3 ULN with symptoms or 5 ULN without symptoms), therapy should be held and reassessed, with consideration of permanent discontinuation if abnormalities persist

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In rare cases, severe reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) have been reported

Combination therapy works well alongside retinoids, hyaluronic acid, and growth factors

Evidence type matters because laboratory studies, animal models, formulation studies, and human clinical data answer different questions

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