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Current Evidence on Semaglutide and Musculoskeletal Pain Despite these potential mechanisms, there is limited direct research specifically investigating semaglutides effects on musculoskeletal pain or back pain

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p53 transcriptionally activates the expression of GLS2 (Jennis et al., 2016) and SAT1 (Ou et al., 2016) (a polyamine catabolic enzyme) and transcriptionally represses SLC7A11 (Jiang et al., 2015)