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Researchers became interested when preclinical studies demonstrated that adding glucagon receptor agonism to incretin-based therapy produced metabolic effects that exceeded those of GLP-1 or GIP activation aloneparticularly in energy expenditure and hepatic lipid metabolism

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Int J Mol Sci 11:268287 Canesi L, Viarengo A (1997) Age-related differences in glutathione metabolism in mussel tissues ( Mytilus edulis L)