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Replacing the C-domain loop of IGF1 with a short GGGG loop completely abolishes its binding to IGF1R 19 (Fig

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Retatrutide's TRIUMPH-4 trial reported nausea in 38.1-43.2% of participants, dysesthesia in 8.8-20.9% (dose-dependent), and discontinuation rates of 12.2-18.2%

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