Storage conditions directly affect potency, and degraded semaglutide can deliver less active compound per milligram than the label states
According to Novo Nordisk prescribing information, similar exposure is achieved across injection sites, including the abdomen, thigh, and upper arm, making differences between these sites clinically minor
Furthermore, a meta-analysis of eight trials comparing semaglutide OW with SGLT2is found that semaglutide OW, at a dose of 1 mg, was significantly more effective in reducing weight and improving HbA1c than the SGLT2is evaluated (statistically meaningful at the 0.05 significance level) [20]
Semaglutide isnt for everyone with PCOS, but it can be a helpful option for certain individuals
The peptide is also contraindicated in pregnant and breastfeeding women [34]
Weekly injections with regular monitoring