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[DOI] [PubMed] [Google Scholar] 127.Rajoria S., Suriano R., Parmar P.S., Wilson Y.L., Megwalu U., Moscatello A., Bradlow H.L., Sepkovic D.W., Geliebter J., Schantz S.P., et al

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In a 24-week open-label Phase I/II clinical trial (Clinicaltrials.gov Identifier: NCT00779194) in patients with active SLE, sirolimus treatment increased the proportion of circulating Foxp3+ Tregs, suppressed IL-17 and IL-4 secretion, and facilitated glucocorticoid tapering (mean prednisolone dose reduced from 23.7 mg to 7.2 mg daily) (236)

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Progesterone amplifies oxidative stress signal and promotes NO production via H 2 O 2 in mouse kidney arterial endothelial cells