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According to clinical studies by Natalia et al., antidepressants, including MTZ, are generally safe for patients with epilepsy when used at therapeutic dosages (Grska et al

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In their review of the evidence, FDA scientists flag potential safety concerns and a lack of consistent data

Metabolic abnormalities induced dysregulation of the activities of TOR and AMPK could result in their unresponsiveness to additional energy demand at cellular level

Some published studies have examined co-administration and found additive effects in certain models, though the mechanistic basis for interaction is not fully established

Protective role of melatonin in neonatal diseases