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Aging (Reduced Synthesis Capacity) As you age, production of glutathione declines due to: Reduced activity of gamma-glutamylcysteine ligase (GCL) , the rate-limiting enzyme in glutathione synthesis Decreased cellular energy (ATP) to fuel glutathione recycling Lower levels of precursor amino acids (especially cysteine and glycine) Studies show glutathione levels drop 10-15% per decade after age 40 [3]

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Psychiatry Res 187:4546 Nafissi S, Saadat I, Saadat M (2011) Genetic polymorphisms of glutathione S -transferase Z1 in an Iranian population

Energy and Antioxidant Effects Are Linked to Mitochondrial Health The mitochondria produce ATP , the molecule that powers virtually every cellular function in the body

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Lateral gene transfer and parallel evolution in the history of glutathione biosynthesis genes (free full text)