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If e-cigarette use helps a smoker to completely quit combustible tobacco use ( 2a and 3d in Figure 17-1), some degree of e-cigarette risk could still generate a net health benefit, as long as exposure to e-cigarettes is temporary and the benefit exceeds net short-term risk

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The latter had significant excess mortality from all causes (HR = 1.25, CI = 1.081.46), but not from heart diseases (HR = 1.16, CI = 0.851.59), malignant neoplasms (HR = 1.17, CI = 0.831.67), and all smoking-related diseases (HR = 1.19, CI = 0.971.46)

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Among smokers, heart disease is the primary cause of death