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Metformin is similar to berberine in that it also lowers blood sugar levels, and its possible that berberine could increase metformin levels

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These M2-polarized macrophages, in turn, promote tumor progression by enhancing the proliferation and migration of EOC cells ( Figure 5 ) (121)

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With the exception of GSH total levels, in which there was a trend to lower levels in serum from patients with ovarian neoplasms compared to healthy individuals, other thiols were mainly in the protein bound form and not free in plasma

doi:10.1016/j.heares.2009.06.009 92