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GLP-1RAs and Hypertension GLP-1RAs are known to have a positive impact on systemic BP levels and, although the precise mechanisms behind their antihypertensive properties are not fully understood, their association with BP modulation has been frequently reported in clinical trials

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Obesity is characterized by chronic low-grade systemic inflammation, with elevated levels of pro-inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-), and C-reactive protein

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This may cause mild and transient cyanosis due to a right-to-left shunt

Interfaces 9 , 909918 (2017)