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Niraparib showed promising activity in preclinical models and phase I clinical trials, achieving its pharmacodynamic target for PARP inhibition in epithelial ovarian cancer, particularly in patients who have responded to platinum-based chemotherapy 167 (Fig

Ethics declarations Ethics approval and consent to participate Informed consent was obtained from all individual participants included in the study, following approval by Comitato Etico Territoriale CET Lazio Area 5 (Prot

10.1038/s41579-020-0433-9 33 FerreiraR

It binds the GIP receptor with an affinity comparable to that of native GIP and binds the GLP-1 receptor with lower affinity, creating a signaling profile that favors GIP activity

doi:10.1056/nejmoa2500969

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