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The most common side effects involve the digestive system (mild nausea, occasional vomiting, diarrhoea, constipation, or bloating), particularly during the dose escalation phase

This dietary requirement can be fulfilled by foods such as meat, beans, cheese, and eggs

Modifications: Semaglutide has additional modifications (94% homology with GLP-1), which increase its half-life up to 6-8 days, and it can be injected weekly rather than daily

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Moreover, PAS* has immune signaling capacity and induced cytokines IL-1, IL-6, IL-8, IL-10 and TNF- production in human peripheral blood mononuclear cells (PBMCs) [48]