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More scientific evidence is needed to confirm long-term effectiveness and safety

Certain patients benefit from soluble fiber supplementation, dietary fat modulation, or extended spacing between dose increases

In BV2 and N2a cells treated with amyloid (A), berberine promotes cell proliferation, inhibits the activity of caspase-3, and reduces the rate of apoptosis, in addition, berberine promotes cell viability via the microRNA (miR)-188/nitric oxide synthase 1 (NOS1) pathway (Chen M

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Conversely, chronic administration significantly alleviates depression-like symptoms, independent of weight loss or food intake, highlighting its direct impact on mood regulation [20, 21]