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This review highlights the complex interplay between vitamin D and serotonin synthesis and the potential to enhance the efficacy of SSRIs in the treatment of various neuropsychiatric disorders.The synergistic mechanism is likely based on vitamin D altering the levels of TPH2, SERT and MAO-A, which play critical roles in regulating serotonin level in the brain

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Smith GL, Smith BD, Buchholz TA, Liao Z, Jeter M, Swisher SG , Hofstetter WL, Ajani JA, McAleer MF, Komaki R, Cox JD