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In the G1 to S transition, the ubiquitin ligase SCFskp2 (ubiquitin-proteasome system) is responsible for downregulating p21 and p27 to ubiquitination before degradation

2019 May 7;12(1):637

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For elution of the target protein, the interaction to the ligand is resolved by changing the buffer conditions, for example, the pH value, or by adding a specific competitor that supplants the target protein from the ligand resulting in dissociation of the target, while the ligand remains immobilized on the stationary phase

354,355 The molecular mechanism by which ferroptosis is involved in the occurrence and development of UC is shown in Fig

10.3945/ajcn.115.120931 170 LeiL.LiuY