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The 2-year STEP 5 study discussed here aimed to assess the sustained impact of weekly subcutaneous semaglutide 2.4 mg, in conjunction with behavioral interventions, on body weight and cardiometabolic risks among non-diabetic adults grappling with obesity (BMI 30 kg m2) or overweight (BMI 27 kg m2 with at least one related comorbidity)

Neurobiol Dis 33:405414 Schirmer RH, Krauth-Siegel RL, Schulz GE (1989) Glutathione reductase

Skin-related reactions are also common, including irritation, redness, itching, or allergic responses from the adhesive or active ingredients in the patch

This favorable preclinical safety profile has led investigators to advocate for the initiation of formal human trials [52, 83]

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Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies