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"This sad mood makes it hard for people to quit, especially in the first few days," said Jeffrey Meyer, the lead researcher and a senior scientist at the Centre for Addiction and Mental Health in Toronto

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The researchers used a double-blind three-group randomized clinical trial to evaluate the effect of varenicline (1 mg twice daily) compared to a matched placebo or a text message-based intervention known as This is Quitting) on vaping reduction in a sample of 261 youth between 16 and 25 years of age who were vaping 5+ days per week and smoking tobacco no more than 4 days per week

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The FDA only approved PG for limited low dose use up to 7 days for products such as Miralax