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Reduced blood flow from nicotine Nicotine causes vasoconstriction, which narrows the small vessels that supply your lips

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e.g., investigating the endothelial nitric oxide synthase (eNOS) activity in response to maternal smoking, whereby endothelial cells (ECs) were harvested from fetal umbilical veins immediately after postpartum (Andersen et al., in vitro experiments are costly, and only a limited set of experimental parameters are financially feasible

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