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Most patients begin to notice some weight loss within the first month of starting semaglutide GLP-1 treatment

In conclusion, GLP-1 agonists are a promising treatment option for weight loss in PCOS patients

Since renal medullary cells, whose role is to concentrate urine, are constantly exposed to extremely high levels of sodium chloride and urea, the accumulation of betaine in renal medullary cells helps balance the hypertonicity in interstitial fluid (Kempson et al., 2014)

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Annals of Internal Medicine, 116(8), 609614