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Dose reduction for maintenance Some researchers step down their dose after reaching target weight
While people are losing weight, theyre building momentum, feeling positive, and seeing changes in their blood work
In December 2025, Eli Lilly announced topline results from the phase-3 TRIUMPH-4 clinical trial evaluating the safety and efficacy of retatrutide in adults with obesity or overweight and knee osteoarthritis, and without diabetes, as an adjunct to healthy diet and physical activity.
Fatty liver reversal: Preliminary research shows reductions in liver fat and improvements in liver enzyme levels
Crohns Colitis 18 , 10911101 (2024)
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