However, for those who have special conditions, are deficient, vegan or really want to optimise fat loss, taking a bit on the side can be more beneficial than relying on diet alone
At maintenance, the effect is usually steadier and milder than the first-week change
Patel et al.Lancet 2007
Derosa et al., 2025)
As someone who has watched this sector from inside the pharmaceutical world, I can tell you the most important question isnt just, Which one works better? but rather, Which one is actually worth my money over years, not months? What follows is a hardnosed look at cost: sticker price, coverage, outofpocket dynamics, and the bangforbuck calculus around weight loss results
Canagliflozin and renal outcomes in type 2 diabetes: results from the CANVAS Program randomised clinical trials