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Likely it is from southern Bolivia and Northern Argentina and is a combination of two Nicotiana species, Nicotiana sylevestris, and Nicotiana tomentosiformis back from around 5000 BC

Individuals with a predisposition to these conditions may experience exacerbated symptoms and a more aggressive disease course if they continue to smoke

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another brand sells pouches with 13 milligrams of nicotine per pouch