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However, the BHMT reaction is limited to the human liver and kidney since BHMT is expressed primarily in the hepatocytes and kidney cortex (Sunden et al., 1997)

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After he died in 1984, other physicians and naturopaths took up prescribing "intravenous micronutrient therapy" with unsubstantiated health claims for treating fatigue, low energy, stress, anxiety, migraine, depression, immunocompromised, promoting weight loss, and more

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Phosphatidylethanolamine-binding protein 1 (PEBP1) and arachidonate 15-lipoxygenase (ALOX15) can interfere with phospholipid alcohol synthesis and induce ferroptosis [5, 52]

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1 (download TIF Uncut western blot for Fig

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Furthermore, when using cholesterol hydroperoxide (ChOOH, a specific GPX4 substrate) as a stressor, compound 102 could activate GPX4 in intact cells and protect them from ChOOH toxic effects ( Supplementary Figure S12B )

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