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These tests are appropriate screening tests, but each has disadvantages relative to the tier 1 tests. In terms of benefits of CTC, the MSTF describes lower risk of perforation compared with colonoscopy and write, CT colonography appeals to a niche of patients who are willing to undergo bowel preparation and are concerned about the risks of colonoscopy. In terms of risks and tradeoffs, the MSTF describe the requirement for bowel preparation, extracolonic findings, inferior sensitivity compared to other screening tests and radiation exposure

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