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Interestingly, while downregulation of HIF-1 under hypoxia was accompanied by higher levels of hydroxylated HIF-1, HIF-1 hydroxylation was even downregulated by CSE under normoxic conditions

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These restrictions can be imposed for a variety of reasons, such as protecting domestic industries, safeguarding national security interests, or maintaining cultural and ethical standards

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These exceptions were written because ASHRAE and the IMC both recognize a project has to make financial sense