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10.1038/nrneurol.2017.147 301 WangC.ReidG.MackayC

Genc, H

Underexplored peptide systems are highlighted to illustrate points of convergence with established incretin pathways rather than isolation from them

Discussion Recent publications of positive CV outcome trials with SGLT2i (empagliflozin and canagliflozin) and GLP1 RA (liraglutide and semaglutide) and the positive effects of treatment with these drugs utilizing the pathophysiological defects of T2D have caused a paradigm shift in the way the disease is treated [1,2,3,4]

Melanotan 2 , a related peptide with the molecular formula C50H69N15O9 and CAS number 121062-08-6 , is a modification of alpha-MSH