The secretion of incretin hormones from enteroendocrine cells in the gut epithelium, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), potentiates postprandial insulin secretion, a phenomenon known as the incretin effect
Hematoxylin and Eosin (H&E) and Immunohistochemical (IHC) Staining Formalin-fixed and paraffin-embedded rats pancreatic tissue sections were deparaffinized in xylene and rehydrated using graded ethanol into PBS
10.1007/s10787-006-1531-7 [DOI] [PubMed] [Google Scholar] Sikiric P., Seiwerth S., Brcic L., Sever M., Klicek R., Radic B., et al
& Roblin, R
Shabani, A.A
Nevertheless, the imbalance of redox activity is a crucial step in DILI as most hepatotoxic drugs determine a build-up of ROS and induce oxidative stress by different mechanisms such as an increase in intracellular oxidants and depletion of antioxidants that finally lead to mitochondrial dysfunction [60,61]