COPD mechanisms include mucus hypersecretion (chronic bronchitis), tissue destruction (emphysema), and small airway inflammation with fibrosis
Conversely, inhibition of the Wnt/-catenin signaling pathway increases ciliary cell count, epithelial polarity, and barrier function, while inhibiting EMT, thereby reversing COPD characteristics
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National comprehensive cessation services with full or partial cost-coverage are available to assist tobacco users to quit in only 31 countries, representing a third of the world's population (4)