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This change has already caused the rate of lung cancer in males to level off

Effects on the heart include increased heart rate and blood pressure followed by decreased heart rate and blood pressure

Toxicol Appl Pharmcol

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The Centers for Disease Control and Prevention or CDC, for instance, has stated that cigarette smoking harms nearly every organ of the body, causes many diseases, and reduces the health of smokers in general. Some health risks associated with cigarette smoking include stroke, coronary heart disease, and cancers almost anywhere in the body

doi:10.1093/jnci/92.2.106