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97% achieved an end-of-treatment response and 90% achieved SVR12.[32] Sofosbuvir-Based Treatment in Phase 3 Trials : In a pooled analysis of data from phase 3 trials using sofosbuvir-based regimens, investigators compared HCV treatment responses in participants receiving opioid substitution therapy during treatment (n = 194) with participants not receiving opioid substitution therapy (n = 4,549).[27] There were no significant differences in SVR12 rates (94% in those receiving opioid substitution therapy versus 97% for those not receiving opioid substitution therapy).[27] Sofosbuvir-Velpatasvir (SIMPLIFY) : In this single-arm, open-label, phase 4 study, 103 participants with chronic HCV genotype 1, 2, 3, 4, 5, or 6 infection and recent (within 6 months) injection drug use were treated with a 12-week course of sofosbuvir-velpatasvir.[22] During the treatment course, 59% (61 of 103) participants were receiving opioid substitution therapy, and 74% (76 of 103) had used injection drugs in the month prior to starting treatment.[22] A total of 97% (100 of 103) participants completed treatment

According to budget documents increasing tax has helped reduce the number of smokers in the country - dropping from about 25% in 1993 to less than 15% in 2013
[1] The film lasts approximately 87 minutes
We also calculated the differences between the patients baseline and follow-up at 3 months values for body weight (including the percent difference), daily number of cigarettes, and both the systolic and diastolic blood pressure (including percent difference)
The impact this promotion has had is especially positive given the trend towards reduced alcohol consumption in Canada and provides a boost to U.S