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The potential influence of literacy and internet availability might have led to sampling bias in terms of including more participants who are educated and have better socioeconomic status
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doi:10.1016/s0196-0644(89)80841-8
Tobacco smoke can negatively impact the efficacy of certain medications, so patients who smoke or vape may require higher doses
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Smoking cigarettes increases the risk of many types of cancer (especially lung cancer, but also colorectal cancer, head and neck cancers, including esophagus, kidney, liver, lower urinary tract, myeloid leukemia, pancreas, stomach, and possibly breast and skin cancer), as well as atherosclerotic cardiovascular disease and chronic obstructive pulmonary disease
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