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A recent network meta-analysis assessing oral health effects across non-combustible nicotine products did not identify any eligible randomized controlled trials on nicotine pouches, and the relatively short follow up period of the included studies did not allow for evaluation of their potential impact on oral carcinogenesis (60, 61)

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In the last few decades, the increasing trend of thyroid cancer coincides with the growing trend of obesity

10.1016/j.placenta.2020.05.003 20