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The smaller than anticipated sample size meant the study was not sensitive enough to pick up a definitive finding for the second comparison, although analyses suggest combination nicotine therapyie, use of a slow release nicotine patch, together with a faster-acting oral nicotine product (in this case a nicotine e-cigarette)could result in five to ten more smokers per 100 quitting long-term than with monotherapy (ie, nicotine patches alone)

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These life-threatening complications are principally the hallmark of vEDS together with gastrointestinal and uterine fragility, but they may occur also in other EDS subtypes, including rare individuals with a severe form of cEDS [16]