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IR induced metabolic disturbances lead to degradation of brain function, and prolonged uncontrolled high blood glucose levels adversely affect a variety of metabolic pathways such as oxidative stress, formation of advanced glycosylation end products (AGEs), and protein kinase C activation, while metabolic disturbances inducing cerebral microvascular damage affect the extent of cognitive impairment (1, 7)

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However, feeding state dramatically affects receptor-level activity

72 h post-administration, the signal from P-Mn/TI@mHSA in the blood was significantly diminished

Hypertension is a major risk factor for cardiovascular disease, stroke, and chronic kidney diseaseconditions that frequently coexist with metabolic disorders such as type 2 diabetes

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